What cells express CD11c?
CD11c is abundantly expressed on monocytes, granulocytes, on tissue macrophages, on a subset of dendritic cells, and at low level on neutrophil, but can be expressed as well on a subset of B cells, T cells, and NK cells, with expression level varying from dim to bright (8).
Where is CD11c expressed?
CD11c is a type I transmembrane protein that is expressed on monocytes, granulocytes, a subset of B cells, dendritic cells, and macrophages and may be demonstrated on B-cell chronic lymphocytic leukemia, marginal zone lymphomas, and hairy cell leukemia.
Do t cells express CD11c?
CD11c is an α integrin classically employed to define myeloid dendritic cells. Although there is little information about CD11c expression on human T cells, mouse models have shown an association of CD11c expression with functionally relevant T cell subsets.
Do monocytes express F4 80?
Monocytes that circulate in the bloodstream also express F4/80 on the surface, but the level is lower than on tissue macrophages, indicating another correlation between the level of F4/80 and the adhesion properties of the corresponding mononuclear blood cell (Gordon and Austyn, 1981).
Do CD8 T cells express CD11c?
CD11c is a member of the β2-integrin family typically used to define myeloid dendritic cells (DCs). Recent reports identify CD11c-expressing CD8+ T cells as a new subset of CD8+ regulatory T cells (Treg).
What is a circular CD11c + DC?
Circulating CD11c + DCs are typically CD11c high and major histocompatibility complex (MHC) class IIhigh but lineage-negative (Lin –), i.e., lacking markers for other cell lineages, such as T cells, monocytes, B cells, NK cells, granulocytes, and erythroid cells.
What is the CD11c- subset of CD8?
As described above, the CD11c − subset is specialized to produce significantly greater quantities of IFN alpha than their monocyte-derived counterparts. Monocyte-derived DCs, but not the lymphoid derived CD11c − DCs also produce IL-15, an important factor for the activation and differentiation of CD8 + T cells ( Ma et al., 2000 ).
What is CD11c in non Hodgkin lymphoma?
Immunohistology of Non-Hodgkin Lymphoma. CD11C. CD11c is a type I transmembrane protein that is expressed on monocytes, granulocytes, a subset of B cells, dendritic cells, and macrophages and may be demonstrated on B-cell chronic lymphocytic leukemia, marginal zone lymphomas, and hairy cell leukemia.
Where are CD11c+ lymphoid tissue dendritic cells found?
CD11c+ Lymphoid Tissue Dendritic Cells. Human CD11c+ LT DCs are found in the thymus, spleen, peripheral lymph nodes, and other secondary lymphoid tissues, and in small numbers in the blood. They can be divided into two major subsets: blood DC antigen (BDCA)-1+ and BDCA-3+ CD11c+ DCs.
